Understanding a key protein in the herpes simplex virus
Functions of the largest HSV-1 virion protein, pUL36
This study is looking at a specific protein in the herpes simplex virus that causes cold sores and other serious issues, to find new ways to stop the virus from spreading and help improve treatments for people dealing with these infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11116441 on NIH RePORTER |
What this research studies
This research investigates the role of the pUL36 protein in the herpes simplex virus (HSV-1), which is known to cause persistent infections leading to conditions like cold sores, blindness, and even encephalitis. The study aims to explore how this protein contributes to the virus's ability to mature and replicate, potentially identifying new targets for antiviral drugs. By focusing on the virus's life cycle, the research seeks to develop compounds that can inhibit its replication or prevent disease altogether, which could significantly improve treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from herpes simplex virus infections, particularly those experiencing severe symptoms like ocular disease or recurrent cold sores.
Not a fit: Patients who do not have herpes simplex virus infections or those with mild, non-recurring symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that effectively treat or prevent herpes simplex virus infections.
How similar studies have performed: Previous research has shown promise in targeting viral proteins for antiviral drug development, indicating that this approach could be effective.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Desai, Prashant J — Johns Hopkins University
- Study coordinator: Desai, Prashant J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.