Understanding a Heart Protein's Role in Rhythm Problems
A hERG1 potassium channel subdomain is trafficked to the cardiac nucleus: mechanisms and targets of the hERG1NP
This project looks at a specific protein in heart cells to understand why some young people develop dangerous heart rhythm issues like Long QT Syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11101330 on NIH RePORTER |
What this research studies
Our hearts rely on a protein called hERG1 to maintain a steady rhythm, and problems with this protein can lead to a condition called Long QT Syndrome Type II, which can be very serious, especially in young hearts. We recently found a new, smaller piece of the hERG1 protein, called hERG1NP, that travels into the heart cell's control center, the nucleus. This new protein seems to change how the main hERG1 protein works, potentially affecting heart rhythm. We want to learn exactly how hERG1NP influences heart function and contributes to rhythm problems in developing hearts.
Who could benefit from this research
Good fit: This foundational research is relevant for patients with Long QT Syndrome Type II, especially children and adolescents, and those at risk for sudden infant death syndrome.
Not a fit: Patients whose heart rhythm conditions are not linked to the hERG1 channel or Long QT Syndrome Type II may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of heart rhythm disorders in children and adolescents, potentially guiding new ways to prevent or treat conditions like Long QT Syndrome Type II and sudden infant death syndrome.
How similar studies have performed: The discovery of the hERG1NP protein and its nuclear targeting is a novel finding, building upon existing knowledge of hERG1 channel function.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Jones, David K. — University of Michigan at Ann Arbor
- Study coordinator: Jones, David K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.