Understanding a Genetic Factor for Alzheimer's in African Americans
Investigating an African American-specific APOE genetic variant using hiPSC
This project explores how a specific genetic change in African Americans might increase their risk for Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11175524 on NIH RePORTER |
What this research studies
This project uses human stem cells to create models of brain cells, including neurons, astrocytes, and microglia. Researchers will introduce a specific genetic variant, APOE R145C, into these cells from both healthy individuals and those with Alzheimer's, including African American patients. By comparing these cells, they aim to discover how this genetic change affects processes related to Alzheimer's, such as how proteins like amyloid-beta and tau behave. This work helps us understand why Alzheimer's risk is higher in African Americans with this genetic variant.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients, but it focuses on understanding Alzheimer's risk in African Americans aged 21 and older.
Not a fit: Patients who do not have the APOE R145C variant or are not of African ancestry may not directly benefit from the specific findings of this particular genetic mechanism.
Why it matters
Potential benefit: If successful, this work could uncover new ways to prevent or treat Alzheimer's disease, especially for African Americans who carry this specific genetic variant.
How similar studies have performed: While the APOE R145C variant's association with AD risk in African Americans has been identified, the specific mechanisms by which it exacerbates AD are largely unknown, making this a novel investigation.
Where this research is happening
Scottsdale, United States
- Arizona State University-Tempe Campus — Scottsdale, United States (Active)
Researchers
- Principal investigator: Brafman, David a — Arizona State University-Tempe Campus
- Study coordinator: Brafman, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.