Understanding a Gene's Role in Atrial Fibrillation
Pitx2 in atrial fibrillation
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10982486
This project explores how a specific gene, Pitx2, is connected to atrial fibrillation, a common irregular heartbeat.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10982486 on ClinicalTrials.gov |
What this research studies
The Pitx2 gene helps control how the heart develops, and we know it's linked to atrial fibrillation (AF), but we don't fully understand why. Previous genetic studies found a connection between a specific region on chromosome 4q25, where Pitx2 is located, and early-onset AF, especially in patients without other common heart risk factors. Patients with this genetic link are also more likely to experience a type of stroke. Our team previously showed that lower levels of Pitx2 in mice led to AF, and other researchers have confirmed this finding. We are now using advanced genetic tools to identify which other genes Pitx2 interacts with, especially those involved in AF, inflammation, and how the body handles stress.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient recruitment, but future studies might focus on individuals with early-onset atrial fibrillation, particularly those with the 4q25 genetic variation.
Not a fit: Patients without atrial fibrillation or those whose condition is not linked to the Pitx2 gene may not directly benefit from this specific genetic understanding.
Why it matters
Potential benefit: Understanding how Pitx2 contributes to AF could lead to new ways to prevent or treat this irregular heartbeat, especially for those with a genetic predisposition.
How similar studies have performed: Initial findings linking Pitx2 to AF in mice have been successfully replicated by multiple research groups, suggesting a strong foundation for this work.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTIN, JAMES F — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MARTIN, JAMES F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.