Understanding a bone disorder that affects children
Pathogenesis of Multicentric Carpotarsal Osteolysis
['FUNDING_R21'] · WASHINGTON UNIVERSITY · NIH-10708888
This study is looking into multicentric carpotarsal osteolysis syndrome (MCTO), a genetic condition that causes bone problems in young kids, to find out how it works and discover new ways to help those affected.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10708888 on ClinicalTrials.gov |
What this research studies
This research investigates multicentric carpotarsal osteolysis syndrome (MCTO), a serious genetic condition that leads to severe bone destruction in young children. The study aims to explore the underlying mechanisms of the disease, focusing on the role of specific genes and proteins involved in bone health. Researchers will analyze blood samples to identify biomarkers that could indicate how the disease progresses and how it affects bone cells. By understanding these processes, the research hopes to uncover potential new treatment strategies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children diagnosed with multicentric carpotarsal osteolysis syndrome.
Not a fit: Patients with other unrelated bone disorders or those outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for children suffering from MCTO.
How similar studies have performed: Previous research has identified genetic mutations related to MCTO, but this study aims to explore novel aspects of the disease, making it a potentially groundbreaking investigation.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUMM, STEVEN R — WASHINGTON UNIVERSITY
- Study coordinator: MUMM, STEVEN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.