Uncovering Hidden Cell Functions in ALS
Illuminating cellular dark matter through the development of novel chemical tools
This project aims to develop new chemical tools to understand the unknown functions of certain cell components, especially those involved in diseases like ALS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11126555 on NIH RePORTER |
What this research studies
Our cells contain many components whose roles are not fully understood, much like 'dark matter' in the universe. This project creates new chemical tools to illuminate these hidden cellular processes. We plan to develop ways to precisely modify and observe specific RNA molecules, particularly those linked to genetic amyotrophic lateral sclerosis (ALS). Additionally, we will create methods to synthesize and deliver specific lipid molecules within living cells to uncover how these fats affect cell behavior. This foundational work seeks to reveal the molecular mechanisms behind diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but it focuses on understanding the underlying biology of diseases that affect individuals with conditions like ALS.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this research could uncover fundamental causes of diseases like ALS, leading to the development of entirely new treatment strategies.
How similar studies have performed: This project involves developing novel chemical technologies while also building upon existing tools and approaches previously developed by the research team.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Devaraj, Neal Krishna — University of California, San Diego
- Study coordinator: Devaraj, Neal Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.