Ultrasensitive home and neighborhood sensors to detect harmful air chemicals

Project 3 - Development and Field Application of Novel Ultrasensitive Devices for the Measurement of Airborne VOCs

NIH-funded research University of Louisville · NIH-11112461

New ultraprecise air sensors and a portable analyzer will measure tiny amounts of harmful volatile chemicals in homes and nearby outdoor air to help people worried about air-related heart and metabolic risks.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Louisville NIH-funded
Lab location1 site (Louisville, United States)
Project IDNIH-11112461 on NIH RePORTER

What this research studies

Researchers will deploy networks of small, low-cost sensors and a portable high-resolution instrument called MOIRA to measure volatile organic compounds like acrolein, benzene, and trichloroethene in indoor and outdoor air. The small sensors use new surface chemistries and MEMS fabrication to improve sensitivity and selectivity, while MOIRA provides high-time-resolution GC-MS confirmation. The team will compare indoor versus outdoor levels and study which household activities or building features raise exposures. Data collected will help pinpoint common sources of exposures and guide ways to reduce them.

Who could benefit from this research

Good fit: People with heart disease, diabetes, or other cardiometabolic conditions who live near industrial sites, Superfund areas, or who are concerned about indoor air quality would be ideal candidates to participate.

Not a fit: Patients seeking immediate medical treatment or whose symptoms are unrelated to airborne chemical exposure are unlikely to receive direct health benefit from participation.

Why it matters

Potential benefit: If successful, this work could help people reduce exposure to VOCs linked to heart and metabolic diseases by identifying sources and enabling smarter mitigation strategies.

How similar studies have performed: Previous studies using portable GC-MS and sensor networks have detected VOCs successfully, but combining new ultrasensitive MEMS sensors with expanded MOIRA monitoring for indoor home studies is a novel advance.

Where this research is happening

Louisville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cardiometabolic DiseaseCardiometabolic Disorder
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.