Ultra–high-resolution MRI to see activity across brain layers
Resolving Human Brain Activation Across Cerebral Cortical Layers with Line-Scan Functional MRI
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11401572
This project uses very high-resolution MRI scans to image how different layers of the brain's cortex signal to each other in people who can safely undergo 7T MRI.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11401572 on ClinicalTrials.gov |
What this research studies
If you join, you'll first have a standard fMRI scan to find active brain 'hubs', then undergo targeted ultra-high-resolution 'line-scan' MRI sessions at a 7 Tesla scanner that focus on tiny columns through the cortex. The line scans sample at about 0.125 mm resolution and are placed perpendicular to the cortical surface to try to separate signals from different cortical layers. Researchers will compare these layer-specific signals with conventional whole-brain fMRI to look for patterns of input and output signaling between areas. Sessions may be longer than a typical MRI and require screening for MRI safety and the ability to remain still in the scanner.
Who could benefit from this research
Good fit: Adults who can safely undergo 7T MRI (no incompatible implants, pacemakers, or metal fragments), can lie still for extended scans, and can travel to Stanford are the most suitable participants.
Not a fit: People with MRI-incompatible implants, severe claustrophobia, or those seeking immediate clinical treatment are unlikely to receive direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could improve understanding of how brain regions communicate, which may eventually help diagnose or guide treatments for neurological and psychiatric conditions.
How similar studies have performed: Prior laminar fMRI work at 7T has shown layer-specific signals are measurable, but whole-brain temporal coverage is limited and the proposed ultra-high-resolution line-scan approach is relatively new.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POLIMENI, JONATHAN R — STANFORD UNIVERSITY
- Study coordinator: POLIMENI, JONATHAN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.