Ultrafast 3-D Voltage Imaging in Rodents
Official title: Computational volumetric one-photon voltage imaging in rodents
Funded at Rockefeller University · NIH-11412623 · Data updated 2026-11-12
A new imaging approach will let scientists watch the brain’s electrical activity in three dimensions at millisecond speed in awake rodents.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $169,500 |
| NIH project number | 5R21EY035958-03 |
| Project ID | NIH-11412623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group; preclinical rodent research.
✕Less likely to help
No direct patient benefit at this stage; findings may inform future human research.
What this research studies
This project aims to develop and demonstrate a groundbreaking imaging system that records large networks of neurons in 3-D with very high temporal resolution. By combining advanced voltage indicators with fast, volumetric recording, researchers hope to capture how brain circuits coordinate during behavior. The work focuses on the cortex and hippocampus in awake, behaving animals, using rodent models to map real-time neural dynamics. If successful, it could provide a powerful tool for understanding how cognitive processes emerge from network activity.
Why it matters
Potential benefit: Could yield a new way to study brain function and disorders by showing real-time, 3-D neural activity in living animals.
How similar studies have gone: Related imaging approaches have shown promise, but true ultra-fast 3-D volumetric voltage imaging in awake animals is a novel advancement.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Oenol-Noebauer, Tobias — Rockefeller University
- Study coordinator: Oenol-Noebauer, Tobias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.