UCSC-Buck center analyzing cancer genome data to help match tumors with treatments
UCSC-Buck Genome Data Analysis Center for the Genomic Data Analysis Network v2.0
This project builds a large cancer genomics and clinical-outcomes resource and analytic tools to help doctors and patients connect tumor gene patterns with better treatment choices.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11162429 on NIH RePORTER |
What this research studies
They will gather tumor molecular data and linked clinical outcomes from many cancer patients and combine different data types (including single-cell RNA and mutation data). The team will use pathway analysis, integrative machine-learning, and visualization tools to find gene expression signatures that reflect tumor cell states and behavior. These signatures and analytic workflows will be shared widely with the Genomic Data Analysis Network and the broader research community. The goal is to create searchable databases and trained algorithms that can inform future work on matching patients to therapies.
Who could benefit from this research
Good fit: Ideal contributors are cancer patients whose tumor samples and clinical outcome data can be shared for genomic analysis and follow-up.
Not a fit: Patients without tumor genomic testing, without available clinical outcome data, or whose cancer types are not represented in the database may not see direct benefits.
Why it matters
Potential benefit: If successful, this work could help identify molecular patterns that predict which treatments are most likely to work for individual cancer patients.
How similar studies have performed: Large efforts like The Cancer Genome Atlas and other genomics projects have revealed important tumor patterns, but applying those patterns to guide individual treatment is still an emerging area.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Stuart, Joshua Michael — University of California Santa Cruz
- Study coordinator: Stuart, Joshua Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.