UAB Center for Childhood Polycystic Kidney Disease
UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC)
This center is creating shared patient data, samples, lab models, and analysis tools to speed discoveries and better care for people with childhood polycystic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11231581 on NIH RePORTER |
What this research studies
We will build a Childhood Clinical and Translational Resource that collects patient health information and biological samples into a centralized database and biorepository to support clinical research. The team will develop methods to capture patient and caregiver experiences so research is more patient-centered. The Bioengineering Resource will create inducible PKD rat models and use patient-derived iPS cells to grow kidney organoids for studying cyst formation and testing the function of PKD proteins and variants. An informatics and data analytics hub will integrate large-scale omics datasets so researchers across the consortium can analyze genetic and molecular drivers of childhood PKD.
Who could benefit from this research
Good fit: Children and young adults with childhood-onset cystic kidney disease (and their caregivers) who can provide health information and biological samples are ideal candidates.
Not a fit: People without cystic kidney disease or those unable or unwilling to provide samples or participate in clinic visits are unlikely to receive direct benefit from this center.
Why it matters
Potential benefit: If successful, this work could speed development of targeted, more effective treatments and improve care for children with cystic kidney disease.
How similar studies have performed: Consortium biorepositories and organoid/model approaches have previously advanced kidney-disease research, and this center applies those methods specifically to childhood PKD.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Yoder, Bradley K. — University of Alabama at Birmingham
- Study coordinator: Yoder, Bradley K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.