TYR Now: a quick fingertip test for tyrosinemia and PKU management
Official title: A Point of Care-Device for the Determination of Blood Tyrosine (TYR) the "TYR Now"
Funded at Analytical Diagnostic Solutions, INC. · NIH-11398329 · Data updated 2026-11-12
A new point-of-care device will soon measure tyrosine levels quickly at the bedside to help people with tyrosinemia and PKU keep their diets and treatments on track.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Analytical Diagnostic Solutions, INC. NIH-funded |
| Lab location | 1 site (Mount Laurel, United States) |
| Project start | September 10, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $312,453 |
| NIH project number | 1R43DK143768-01A1 |
| Project ID | NIH-11398329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with tyrosinemia or PKU who require regular tyrosine monitoring and dietary management.
✕Less likely to help
Patients who do not have tyrosinemia or PKU or who do not require frequent tyrosine monitoring may not benefit.
What this research studies
This grant supports developing TYR Now, a rapid test you can use where you are, so doctors can see tyrosine levels in minutes instead of days. It aims to improve daily management by guiding diet and medicine adjustments sooner, potentially preventing organ complications. The project focuses on creating a simple, reliable test that works with small blood samples and delivers results quickly in clinic or home settings. Researchers will validate the test against standard lab methods and assess usability for caregivers and patients. If successful, TYR Now could reduce hospital visits and improve quality of life for people living with tyrosinemia and PKU.
Why it matters
Potential benefit: If successful, patients could receive faster, more precise care and fewer health complications from tyrosinemia and PKU.
How similar studies have gone: Previous work on point-of-care tests for metabolic markers suggests rapid tests can improve management, though this exact TYR measurement is novel.
Where this research is happening
-
Analytical Diagnostic Solutions, INC.
Mount Laurel, United States Active
Researchers
- Principal investigator: Harper, Robert — Analytical Diagnostic Solutions, INC.
- Study coordinator: Harper, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.