Types of Type 2 Diabetes in South Asian Adults
Molecular Prediction, Disease Progression, and Type 2 Diabetes (T2D) Phenotypes in South Asians
This project looks at genetic and blood-molecule patterns that predict which South Asian adults with prediabetes or diabetes develop different forms of Type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11254928 on NIH RePORTER |
What this research studies
From the patient perspective, researchers will use health records and stored blood samples from a large group of South Asian adults followed for over a decade to find molecular signs linked to different diabetes types and outcomes. They will analyze genetic data and blood metabolites to distinguish insulin-deficient versus insulin-resistant phenotypes and to see which patterns predict progression from prediabetes to diabetes or higher risk of death. The team builds on preliminary findings showing distinctive insulin-deficient patterns in South Asians and will test whether these molecular markers reliably predict who develops severe disease. Results aim to point toward better-tailored prevention and treatment options for people of South Asian ancestry.
Who could benefit from this research
Good fit: Ideal candidates are adults of South Asian ancestry with prediabetes or Type 2 diabetes, or those enrolled in the Precision-CARRS cohort and willing to link their clinical data and blood samples to research.
Not a fit: People who are not of South Asian descent or individuals under 21 years old are unlikely to directly benefit from the specific findings of this project.
Why it matters
Potential benefit: If successful, this work could help doctors predict which South Asian patients are most likely to develop dangerous forms of T2D and personalize prevention and treatment.
How similar studies have performed: Related research in European populations has identified diabetes subtypes and this team's preliminary South Asian data are promising, but using molecular markers to guide care in South Asians is still relatively new.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.