Tumor tissue and genomic analysis core
Core B: Molecular Pathology and Bioinformatics Core
It collects and analyzes tumor and matched normal tissue from people with cancer using advanced pathology and genetic tests to create detailed profiles for researchers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11181574 on NIH RePORTER |
What this research studies
If my hospital is part of the network, this core would arrange for my tumor and matched normal tissue to be sent to a central lab for processing. They make digital pathology images, extract DNA and RNA from preserved (FFPE) samples, and run whole-exome sequencing and RNA sequencing. Expert bioinformatics pipelines turn those results into data that research teams can use and provide tailored analytic support for each project.
Who could benefit from this research
Good fit: Patients with cancer who have available tumor tissue (FFPE blocks) and matched normal samples at or willing to share samples through participating AACR GENIE sites are ideal candidates.
Not a fit: Patients without available tissue samples, treated outside participating centers, or seeking immediate changes in clinical care are unlikely to benefit directly from this core.
Why it matters
Potential benefit: If successful, this work could help researchers discover new cancer markers and better match patients to targeted treatments or clinical trials.
How similar studies have performed: Similar centralized sequencing and bioinformatics efforts (for example AACR GENIE) have previously helped match tumors to therapies and reveal important genomic patterns, so this approach builds on proven methods.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Berger, Michael F. — Sloan-Kettering Inst Can Research
- Study coordinator: Berger, Michael F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.