Tuberculosis bacteria's protein-recycling machinery
Proteasomal Regulation in Mycobacterium tuberculosis
Researchers are looking at how TB bacteria control a protein-degrading machine to find new ways to stop the infection for people with tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11292936 on NIH RePORTER |
What this research studies
This project studies the proteasome, a protein-degrading complex inside Mycobacterium tuberculosis, to learn how the bacteria tag and deliver proteins for destruction. Scientists use molecular lab work and animal models to map which bacterial proteins are regulated and how that helps TB survive. By pinpointing key steps in this system, the team hopes to reveal weak points that drugs could target. The work is basic lab science rather than a clinical treatment trial.
Who could benefit from this research
Good fit: People with active or latent tuberculosis would be the most relevant group for future treatments arising from this research.
Not a fit: Because this is basic laboratory research, it will not provide immediate treatment or direct benefit to patients looking for current care.
Why it matters
Potential benefit: If successful, this work could point to new drug targets that stop TB bacteria from surviving and make treatments more effective.
How similar studies have performed: Prior studies showed the bacterial proteasome is essential for TB to persist in animals, but turning that knowledge into proven drugs is still in early stages.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Darwin, Katerina Heran — New York University School of Medicine
- Study coordinator: Darwin, Katerina Heran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.