Trop2's role in aggressive prostate cancer
Elucidating the Role of Trop2 in Prostate Cancer
This work focuses on a protein called Trop2 that may help aggressive prostate cancer grow and resist hormone treatment in men.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11310751 on NIH RePORTER |
What this research studies
If you have advanced prostate cancer, this research looks at a cell surface protein called Trop2 that is often higher in aggressive tumors. Scientists will study how Trop2 is activated and cleaved and how those changes help tumors grow and survive despite hormone treatments, using lab-grown cells and tumor samples. The team will map the molecular pathways Trop2 affects to find weak points they could target. The findings are intended to point toward new treatments or future clinical trials for men with castration-resistant prostate cancer.
Who could benefit from this research
Good fit: Men with advanced or castration-resistant prostate cancer, especially those whose tumors show high Trop2 levels, would be most relevant for follow-up studies or trials.
Not a fit: Men with early-stage, slow-growing prostate cancer or cancers not driven by Trop2 are less likely to see direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could reveal new drug targets to stop or slow aggressive, hormone-resistant prostate cancer.
How similar studies have performed: Prior laboratory studies have linked Trop2 to growth and spread in several cancers and suggest it is a promising target, but targeted therapies for prostate cancer remain experimental.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Stoyanova, Tanya I — University of California Los Angeles
- Study coordinator: Stoyanova, Tanya I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.