Tricuspid Valve Maladaptation and New Therapies for Functional Tricuspid Regurgitation
Official title: Tricuspid Valve Maladaptation: Its Stimuli, its Effect on Valve Function, and its Response to Therapy
Funded at University of Texas at Austin · NIH-11534722 · Data updated 2026-11-12
A research team is studying why the tricuspid valve changes and how these changes affect valve leakage, with the goal of developing safer, better treatments for people with functional tricuspid regurgitation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | June 20, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $94,033 |
| NIH project number | 3R01HL165251-05S1 |
| Project ID | NIH-11534722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with functional tricuspid regurgitation or those at risk of developing it, and who could participate in biomedical or translational research.
✕Less likely to help
Patients whose condition does not involve tricuspid valve maladaptation or who cannot participate in the proposed models and analyses may not benefit.
What this research studies
This project looks at how the tricuspid valve adapts and malfunctions in response to heart stress, and how these changes influence valve function and patient outcomes. Researchers have identified valve remodeling in animal models and aim to translate these findings to improved therapies that reduce relapse and procedure risks. The study combines imaging, simulations, and biological analysis to understand who might benefit most from new approaches. Results could lead to therapies that promote healthy valve remodeling or prevent fibrotic changes that worsen leakage.
Why it matters
Potential benefit: If successful, patients with functional tricuspid regurgitation could experience safer, more effective treatments and fewer repeat procedures.
How similar studies have gone: Previous animal studies have shown valve leaflet growth and fibrotic remodeling, suggesting a potential pathway for new therapies, with ongoing work to translate these findings to humans.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Rausch, Manuel Karl — University of Texas at Austin
- Study coordinator: Rausch, Manuel Karl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.