TrialNet Hub for Preventing and Preserving Insulin-Producing Cells in Type 1 Diabetes
Type 1 Diabetes TrialNet Clinical Network Hub
This network runs screening and clinical trials to try to prevent or preserve insulin-producing cells in children and adults at risk for or newly diagnosed with type 1 diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11218878 on NIH RePORTER |
What this research studies
If you join, TrialNet may screen you or your family members for signs of risk for type 1 diabetes and invite eligible people to take part in prevention or early-treatment trials. The Hub coordinates recruitment, consent, study visits, and follow-up across many clinical sites so trials enroll the right people and run smoothly. Studies can include blood tests for autoantibodies, metabolic testing, and investigational immune- or beta cell–protective treatments, with regular clinic visits and safety monitoring. The Hub also shares results and educational materials with participants and the wider diabetes community.
Who could benefit from this research
Good fit: Ideal candidates are people who are relatives of someone with type 1 diabetes, individuals found to have diabetes-related autoantibodies, or people newly diagnosed with type 1 diabetes.
Not a fit: People with long-standing type 1 diabetes who have little remaining beta cell function or who do not meet trial eligibility criteria may not benefit from these prevention-focused efforts.
Why it matters
Potential benefit: If successful, the work could lead to treatments that delay or prevent type 1 diabetes or help preserve natural insulin production after diagnosis.
How similar studies have performed: TrialNet and similar programs have improved understanding of disease risk and tested several immune-based approaches with some promising signals but no definitive cure yet.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Greenbaum, Carla J — Benaroya Research Inst at Virginia Mason
- Study coordinator: Greenbaum, Carla J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.