Treatment for fecal incontinence and urgency
Therapy for Fecal Incontinence and FecalUrgency
This study is looking at new ways to help people with fecal incontinence and urgency, especially older adults and those with neurological issues, by exploring how certain nerves in the colon work and how blocking them might make things better, giving participants a chance to help create better treatments for everyday life.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dignify Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project ID | NIH-10919294 on NIH RePORTER |
What this research studies
This research investigates new therapeutic approaches for fecal incontinence and fecal urgency, conditions that significantly affect the quality of life for many individuals, particularly the elderly and those with neurological disorders. The study aims to explore the role of specific colorectal nerve terminals in these conditions and how inhibiting them may alleviate symptoms. By focusing on the underlying mechanisms, the research seeks to provide a more effective treatment option beyond current management strategies, which often rely on adult diapers and symptom management. Patients participating in this research may have the opportunity to contribute to the development of innovative therapies that could improve their daily lives.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, nursing home residents, women who have experienced anal damage during childbirth, and patients with neurological conditions such as spinal injuries or multiple sclerosis.
Not a fit: Patients with fecal incontinence or urgency due to non-neurological causes or those who do not meet the specific criteria for participation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for fecal incontinence and urgency, significantly improving the quality of life for affected patients.
How similar studies have performed: While there is ongoing research in this area, the specific approach of targeting colorectal afferent terminals for treating fecal incontinence and urgency is relatively novel and has not been extensively tested.
Where this research is happening
Research Triangle Park, United States
- Dignify Therapeutics, LLC — Research Triangle Park, United States (Active)
Researchers
- Principal investigator: Thor, Karl B — Dignify Therapeutics, LLC
- Study coordinator: Thor, Karl B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.