Treating urinary infections during pregnancy to improve birth weight outcomes
A Prospective Randomized Controlled Trial to Evaluate the Impact of Treatment of Asymptomatic Bacteriuria on Low Birth Weight
This study is looking at whether treating pregnant people who have a urinary infection without symptoms can help prevent low birth weight in their babies, and it involves comparing treatment with a placebo in different countries.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project ID | NIH-10939088 on NIH RePORTER |
What this research studies
This research investigates whether treating asymptomatic bacteriuria (a urinary infection without symptoms) in pregnant individuals can reduce the occurrence of low birth weight in newborns. The study will involve a randomized controlled trial in low- and middle-income countries, where pregnant participants will receive either treatment or a placebo. By comparing the outcomes, researchers aim to determine the effectiveness of antibiotic treatment on both maternal and neonatal health. The study is led by experienced investigators with a strong background in maternal-fetal medicine and global health.
Who could benefit from this research
Good fit: Ideal candidates for participation are pregnant individuals diagnosed with asymptomatic bacteriuria, particularly in low- and middle-income countries.
Not a fit: Patients who are not pregnant or those without asymptomatic bacteriuria are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved birth weight outcomes and reduced neonatal morbidity for infants born to mothers with asymptomatic bacteriuria.
How similar studies have performed: Previous research has indicated that treating urinary infections in pregnant women can improve maternal and neonatal outcomes, suggesting this approach may be effective.
Where this research is happening
Research Triangle Park, United States
- Research Triangle Institute — Research Triangle Park, United States (Active)
Researchers
- Principal investigator: Mcclure, Elizabeth M — Research Triangle Institute
- Study coordinator: Mcclure, Elizabeth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.