Treating urinary infections during pregnancy to improve birth weight outcomes
Official title: A Prospective Randomized Controlled Trial to Evaluate the Impact of Treatment of Asymptomatic Bacteriuria on Low Birth Weight
Funded at Research Triangle Institute · NIH-10939088 · Data updated 2026-11-12
This study is looking at whether treating pregnant people who have a urinary infection without symptoms can help prevent low birth weight in their babies, and it involves comparing treatment with a placebo in different countries.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $828,321 |
| NIH project number | 1U01HD115569-01 |
| Project ID | NIH-10939088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are pregnant individuals diagnosed with asymptomatic bacteriuria, particularly in low- and middle-income countries.
✕Less likely to help
Patients who are not pregnant or those without asymptomatic bacteriuria are unlikely to benefit from this research.
What this research studies
This research investigates whether treating asymptomatic bacteriuria (a urinary infection without symptoms) in pregnant individuals can reduce the occurrence of low birth weight in newborns. The study will involve a randomized controlled trial in low- and middle-income countries, where pregnant participants will receive either treatment or a placebo. By comparing the outcomes, researchers aim to determine the effectiveness of antibiotic treatment on both maternal and neonatal health. The study is led by experienced investigators with a strong background in maternal-fetal medicine and global health.
Why it matters
Potential benefit: If successful, this research could lead to improved birth weight outcomes and reduced neonatal morbidity for infants born to mothers with asymptomatic bacteriuria.
How similar studies have gone: Previous research has indicated that treating urinary infections in pregnant women can improve maternal and neonatal outcomes, suggesting this approach may be effective.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Mcclure, Elizabeth M — Research Triangle Institute
- Study coordinator: Mcclure, Elizabeth M
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.