Treating neonatal brain injury by reversing inflammation in macrophages
Official title: Reversing inflammatory macrophage activation as treatment for neonatal intraventricular hemorrhage and hydrocephalus
Funded at Medical University of South Carolina · NIH-10997325 · Data updated 2026-11-12
This study is looking at whether giving azithromycin, an antibiotic that can help reduce inflammation, can improve brain recovery in newborns who have had bleeding in the brain, which can lead to complications like hydrocephalus.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | October 5, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $174,960 |
| NIH project number | 5K08NS112580-07 |
| Project ID | NIH-10997325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are neonates who have experienced intraventricular hemorrhage and are at risk for post-hemorrhagic hydrocephalus.
✕Less likely to help
Patients who are older than infancy or those who have not experienced intraventricular hemorrhage may not benefit from this research.
What this research studies
This research investigates how reversing the activation of inflammatory macrophages can help treat neonatal intraventricular hemorrhage (IVH) and its complications, such as hydrocephalus. The approach focuses on using azithromycin, an antibiotic with anti-inflammatory properties, to shift macrophages towards a healing state, potentially improving brain recovery in affected neonates. By understanding the role of macrophages in brain injury, the research aims to enhance the outcomes for infants suffering from these conditions. The study will involve monitoring the effects of azithromycin on brain inflammation and myelination in neonates.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for infants suffering from brain injuries due to IVH, potentially enhancing their recovery and long-term outcomes.
How similar studies have gone: Previous research has shown promise in using anti-inflammatory treatments like azithromycin for neurological conditions, indicating potential success for this approach.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Miller, Brandon a — Medical University of South Carolina
- Study coordinator: Miller, Brandon a
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Targeting the brain’s fluid system to treat post-hemorrhagic hydrocephalus
This grant explores a new approach to treating post-hemorrhagic hydrocephalus by studying how the brain’s fluid system and immune cells manage CSF after a brain bleed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.