Traumatic brain injury affects nerve connections in the brain.
Official title: TBI leads to degeneration of afferent neuronal projections
Funded at Rutgers the State Univ of Nj Newark · NIH-11012875 · Data updated 2026-11-12
This study is looking at how a moderate traumatic brain injury affects important nerve connections in the brain that help with thinking and memory, using mice to learn about both the short-term and long-term effects of the injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $353,250 |
| NIH project number | 5R01NS127894-03 |
| Project ID | NIH-11012875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are showing cognitive deficits.
✕Less likely to help
Patients with cognitive impairments not related to traumatic brain injury may not benefit from this research.
What this research studies
This research investigates how traumatic brain injury (TBI) leads to degeneration of nerve connections, particularly focusing on the afferent axons from basal forebrain cholinergic neurons that are crucial for cognitive functions. By using a mouse model of moderate TBI, the study aims to understand the immediate and long-term effects of brain injury on these nerve projections. The researchers will explore the signaling mechanisms that may contribute to the degeneration of these axons and how changes in the brain's environment after injury affect neuronal survival and function.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to protect and restore cognitive functions in patients with traumatic brain injury.
How similar studies have gone: Previous research has shown promising results in understanding neuronal degeneration following brain injuries, but this specific focus on afferent axons is relatively novel.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Friedman, Wilma J — Rutgers the State Univ of Nj Newark
- Study coordinator: Friedman, Wilma J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.