Transplanting pig islets and kidneys to treat diabetes and kidney failure
Composite porcine islet-kidney xenotransplants to cure diabetes and renal failure
This study is exploring a new way to help people with diabetes and kidney failure by using pig cells to improve kidney transplants, making it easier for patients to get the treatment they need without the usual risks.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10812378 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating diabetes and kidney failure by transplanting pancreatic islets from pigs along with kidneys. The islets are placed under the kidney capsule of the donor animal for 6 to 8 weeks to allow them to develop a blood supply before being transplanted into patients. This method aims to overcome the limitations of current islet transplantation techniques, which often require living donors and have a high risk of immune rejection. By using pig organs, the research seeks to provide a viable solution for patients with end-stage diabetic nephropathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 diabetes and end-stage renal disease who are in need of a kidney transplant.
Not a fit: Patients with other forms of diabetes or those who do not have kidney failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a long-term cure for patients suffering from diabetes and kidney failure.
How similar studies have performed: Previous studies have shown promise in using similar xenotransplantation techniques, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Sachs, David H — Columbia University Health Sciences
- Study coordinator: Sachs, David H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.