Transplantation without the need for immunosuppression
Immunosuppression-free transplantation through placental mimicry
['FUNDING_OTHER'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-11176616
This study is looking at a new way to help your body accept transplanted tissues and cells without needing strong medications that suppress your immune system, using special cells from the placenta to make the process safer for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-11176616 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to achieve immune tolerance for transplanted tissues and cells without the need for systemic immunosuppression. By focusing on localized immunomodulation, the study aims to develop methods that induce donor-specific tolerance, reducing the risks associated with traditional immunosuppressive therapies. The research explores the use of tolerogenic cells, particularly those derived from the placenta, to maintain this tolerance in the body. This could lead to safer transplantation outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals requiring allogeneic tissue or cell transplants, such as organ transplant recipients.
Not a fit: Patients who are not candidates for transplantation or those with conditions that contraindicate the use of immunomodulatory therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risks of infections and malignancies associated with current transplantation methods.
How similar studies have performed: While the approach of using tolerogenic cells is being explored, this specific method of utilizing placenta-derived cells for transplantation tolerance is relatively novel and has not been extensively tested.
Where this research is happening
TEMPE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEAVER, JESSICA DIANE — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: WEAVER, JESSICA DIANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers