Translational testing framework for environmental exposures across tissues and people
Official title: Project 4
Funded at Texas A&m University · NIH-11398600 · Data updated 2026-11-12
A researcher-led project aims to create a practical testing approach that links lab models to real people to understand how different tissues and individuals respond to hazardous environmental exposures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 20, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $184,205 |
| NIH project number | 5P42ES027704-10 |
| Project ID | NIH-11398600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals or communities at risk of environmental exposure and communities involved in environmental emergency responses.
✕Less likely to help
People not exposed to relevant environmental hazards or not engaged in emergency response contexts may not directly benefit.
What this research studies
This grant focuses on building a translational in vitro-to-in vivo testing strategy using human iPSC-derived tissue models to capture how people and tissues react to complex environmental hazards. The team will develop high-content, high-throughput assays and a read-across framework to estimate hazard from real-life exposures across populations. The work is designed to support first responders and government agencies by providing tools to assess risk and guide cleanup decisions in environmental emergencies. By integrating organotypic cultures with population-based toxicokinetic methods, the project aims to characterize intertissue and interindividual variability in responses.
Why it matters
Potential benefit: If successful, the approach could improve safety assessments and decision-making during environmental emergencies, potentially reducing health risks for exposed communities.
How similar studies have gone: Previous work with multi-tissue read-across and NAMs has shown promise in hazard assessment for complex exposures, supporting feasibility.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Rusyn, Ivan — Texas A&m University
- Study coordinator: Rusyn, Ivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.