Translational Control of Gene Expression in Fungi – Equipment Supplement
Official title: GM148702 Translational Control of Gene Expression in Fungi - Equipment Supplement
Funded at Texas A&m University · NIH-11309788 · Data updated 2026-11-12
A funding opportunity to upgrade equipment at Texas A&M University to study how tiny protein bits inside ribosomes control gene expression in fungi, which could lead to better understanding of metabolism and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $89,487 |
| NIH project number | 3R01GM148702-04S1 |
| Project ID | NIH-11309788 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to individual patients for this grant; laboratory-based research that could inform human health in the long term.
✕Less likely to help
This grant does not involve direct patient participation or clinical treatment.
What this research studies
This grant supports additional equipment that will help researchers examine how upstream peptides inside ribosomes regulate the production of enzymes involved in metabolism. The work focuses on a conserved fungal uORF peptide called the inositol regulatory peptide (IRP) and how it responds to small molecules to stall protein synthesis. By enabling more precise measurements and experiments, the project aims to fill key gaps about when and why these regulatory peptides are translated. The findings could illuminate fundamental cellular processes that underlie health and disease, potentially guiding future therapeutic strategies. Participation would involve ongoing laboratory research at the university using biological samples and experimental assays.
Why it matters
Potential benefit: If successful, the work could improve our understanding of basic cellular control of metabolism, which may inform future health applications and treatments.
How similar studies have gone: Previous research has shown that uORFs can regulate gene expression, with some evidence of conserved mechanisms, but many details remain unresolved.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Sachs, Matthew Steven — Texas A&m University
- Study coordinator: Sachs, Matthew Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.