Transforming harmful blood cell changes into beneficial ones
Official title: Leveraging HSF1 Attenuation to Transform Clonal Hematopoiesis into Beneficial Hematopoiesis
Funded at Case Western Reserve University · NIH-11024540 · Data updated 2026-11-12
This study is looking at how changes in blood cell production as we age can be adjusted to help prevent blood cancers and other diseases, focusing on a protein called HSF1, and it aims to find ways to keep older adults' blood health in better shape.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $735,085 |
| NIH project number | 1R01HL176819-01 |
| Project ID | NIH-11024540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing age-related blood cell changes or are at risk for blood cancers.
✕Less likely to help
Patients who are under 21 years old or do not have any age-related blood cell changes may not benefit from this research.
What this research studies
This research investigates how age-related changes in blood cell production, known as clonal hematopoiesis, can be modified to prevent the development of blood cancers and other diseases. The study focuses on a protein called HSF1, which is involved in cellular stress responses and aging. By using advanced genetic techniques in mouse models, researchers aim to enhance the beneficial aspects of clonal hematopoiesis while minimizing its risks. This could lead to new strategies for improving blood health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of blood cancers and improve overall health in older adults.
How similar studies have gone: Other research has shown promise in manipulating cellular pathways related to clonal hematopoiesis, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Zhao, Chen — Case Western Reserve University
- Study coordinator: Zhao, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.