Transforming B cells to fight HIV
In vivo transformation of chimeric antigen receptor B cells for a functional cure of HIV
This study is exploring a new way to help the immune system fight HIV by changing certain parts of B cells, which make antibodies, so they can better target and neutralize the virus, potentially leading to a long-lasting solution for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884158 on NIH RePORTER |
What this research studies
This research focuses on developing a new method to edit the receptors of B cells, which are crucial components of the immune system, to produce antibodies that can neutralize HIV. By using advanced techniques like CRISPR/Cas, researchers aim to replace specific parts of the B cell receptors with genes that encode broadly neutralizing antibodies against HIV. These modified B cells, referred to as CAR B cells, can replicate and adapt in the body, potentially providing a long-lasting defense against the virus. This approach aims to create a functional cure for HIV by enabling the immune system to respond effectively to the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking innovative treatment options.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV, allowing patients to control the virus without ongoing treatment.
How similar studies have performed: While the approach of editing B cells is innovative, similar techniques have shown promise in other areas of immunotherapy, suggesting potential for success in this novel application.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Farzan, Michael R. — Boston Children's Hospital
- Study coordinator: Farzan, Michael R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.