Transferring mitochondria to improve recovery after stroke
Extracellular Mitochondria Transfer in Gray and White Matter for Ameliorating Sensorimotor and Cognitive Deficits After Stroke
This study is looking at how moving tiny energy factories called mitochondria between brain cells might help people recover better after a stroke, especially by understanding a special change that could make these mitochondria even more helpful for brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11011318 on NIH RePORTER |
What this research studies
This research investigates how transferring mitochondria between cells in the brain can help improve sensorimotor and cognitive functions after a stroke. The study focuses on understanding the mechanisms behind this transfer, particularly the role of a specific modification called O-GlcNAc, which may enhance the protective effects of mitochondria on brain cells. By using advanced techniques like molecular tools and imaging, the researchers aim to uncover how these processes can aid recovery and protect brain tissue from damage. Patients who have experienced a stroke may benefit from the findings of this research, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently suffered a stroke and are experiencing cognitive or sensorimotor deficits.
Not a fit: Patients who have not experienced a stroke or have chronic neurological conditions unrelated to stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly enhance recovery and quality of life for stroke survivors.
How similar studies have performed: Previous research has shown promise in using mitochondrial transfer for neuroprotection, suggesting that this approach could be effective, although the specific mechanisms being studied here are novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hayakawa, Kazuhide — Massachusetts General Hospital
- Study coordinator: Hayakawa, Kazuhide
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.