Traffic-related ultrafine particles affect lung inflammation recovery
Official title: Traffic-Related Ultrafine Particles Disrupt The Resolution Of Lung Inflammation
Funded at Brigham and Women's Hospital · NIH-10999447 · Data updated 2026-11-12
This study is looking at how tiny particles from traffic pollution can make it harder for kids' lungs to heal after inflammation, with the goal of understanding how these pollutants might affect conditions like asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $623,328 |
| NIH project number | 5R01HL168899-02 |
| Project ID | NIH-10999447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 11 years old who have experienced asthma or other airway diseases.
✕Less likely to help
Patients with lung conditions unrelated to environmental factors or those over the age of 11 may not benefit from this research.
What this research studies
This research investigates how tiny particles from traffic pollution can disrupt the body's natural process of resolving lung inflammation, particularly in children. The study aims to understand the mechanisms by which these particles interfere with specialized mediators that help heal lung tissue after inflammation. By examining the effects of these pollutants on lung health, the research seeks to uncover new insights into how environmental factors contribute to chronic respiratory conditions like asthma. The approach includes laboratory experiments and collaborations among experts in environmental health and lung biology.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating lung inflammation and asthma in children exposed to traffic-related air pollution.
How similar studies have gone: Previous research has shown that environmental pollutants can significantly impact lung health, indicating that this study builds on established findings in the field.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Levy, Bruce D — Brigham and Women's Hospital
- Study coordinator: Levy, Bruce D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.