Tracking vision changes in advanced glaucoma
Monitoring of Glaucoma Patients in Advanced Disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11174457
Using AI with central visual field tests and macular eye scans to track and predict vision loss in people with advanced open-angle glaucoma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11174457 on ClinicalTrials.gov |
What this research studies
You would be followed over time with focused tests of your central vision and detailed macular retinal imaging that measure blood vessels and tissue thickness. Researchers will collect these repeated measurements and use new statistical and artificial-intelligence models to find patterns of ongoing loss. The project focuses on eyes where peripheral vision is mostly gone and only the central visual field remains. The goal is to make tools that can detect and predict worsening earlier than current methods.
Who could benefit from this research
Good fit: People with advanced open-angle glaucoma who have mostly lost peripheral vision and retain primarily central vision would be the ideal candidates.
Not a fit: People with early-stage glaucoma, non–open-angle glaucoma types, or those unable to undergo macular imaging or central visual field testing are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help doctors spot worsening earlier and guide treatment to protect remaining central vision.
How similar studies have performed: AI and imaging have helped detect glaucoma before, but applying these methods to monitor and predict progression specifically in advanced glaucoma using macular microvasculature and thickness is relatively new.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOGHIMI ARAGHI, SASAN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: MOGHIMI ARAGHI, SASAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.