Tracking T-cell function over time using advanced flow cytometry
Official title: Time-lapse Flow Cytometry for Kinetic Profiling of T-Cell Function
Funded at Lase Innovation INC. · NIH-10920383 · Data updated 2026-11-12
This study is looking at how T-cells, which are important for fighting cancer, behave over time when they are treated in different ways, to help improve cancer treatments like vaccines and cell therapies for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lase Innovation INC. NIH-funded |
| Lab location | 1 site (Waltham, UNITED STATES) |
| Project start | September 5, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $837,126 |
| NIH project number | 5R44CA281529-02 |
| Project ID | NIH-10920383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients undergoing immunotherapy treatments who can provide T-cell samples for analysis.
✕Less likely to help
Patients who are not undergoing immunotherapy or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research focuses on developing a new method to analyze T-cell function in cancer patients by using time-lapse flow cytometry. The approach involves tracking the behavior and characteristics of T-cells over time in response to various stimuli, which can help in understanding how these immune cells react during cancer treatments. By measuring cytokine secretion and monitoring T-cell exhaustion, the research aims to provide insights that could enhance the effectiveness of immunotherapies like adoptive cell transfers and cancer vaccines. Patient samples will be used to validate the findings, ensuring that the results are relevant to real-world clinical scenarios.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for cancer patients by providing a better understanding of T-cell dynamics.
How similar studies have gone: Other research has shown promise in using advanced flow cytometry techniques for analyzing immune responses, indicating that this approach could be effective.
Where this research is happening
-
Lase Innovation INC.
Waltham, United States Active
Researchers
- Principal investigator: Kwok, Sheldon J.j. — Lase Innovation INC.
- Study coordinator: Kwok, Sheldon J.j.
Related research
Other NIH-funded projects on the same topics.
-
DNA-based optical barcoding for single-cell analysis
A fast-track SBIR project to create a dual-barcoded optical system that links live-cell imaging with single-cell sequencing to study how individual cancer cells behave.
-
New technology for tracking individual cell behavior using DNA barcodes
This study is testing a new way to track and understand how individual cells work in living systems, which could help scientists learn more about diseases and improve lab techniques for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.