Tracking stem cell activity in cornea healing
Live imaging of stem cell dynamics in cornea regeneration
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10684224
This study is looking at how special cells in the eye help heal after an injury, using live mice to see what these cells do in real-time, with the hope of finding better treatments for corneal diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10684224 on ClinicalTrials.gov |
What this research studies
This research investigates how stem cells in the cornea behave during the healing process after injury. Using advanced imaging techniques, researchers will visualize and monitor these cells in real-time within live mice. The study aims to identify the factors that regulate stem cell activity and their role in corneal regeneration, which could lead to new treatments for corneal diseases. By combining live imaging with genetic tools, the research seeks to deepen our understanding of corneal health and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from corneal diseases or injuries that affect their vision.
Not a fit: Patients with corneal conditions that are not related to stem cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve corneal healing and reduce the need for transplants.
How similar studies have performed: Other research has shown promising results in using live imaging techniques to study stem cell behavior, indicating potential for success in this approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROMPOLAS, PANTELEIMON — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: ROMPOLAS, PANTELEIMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.