Tracking RNA and RNPs in cells using new tagging methods
Official title: URIL tags for intracellular RNA tracking and RNP proximity labeling
Funded at Ohio State University · NIH-10935954 · Data updated 2026-11-12
This study is exploring a new way to track RNA and its related proteins in cells to learn more about how they work and interact, which could help us understand diseases like ALS better and lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 27, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $364,674 |
| NIH project number | 5R01GM151731-02 |
| Project ID | NIH-10935954 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults diagnosed with amyotrophic lateral sclerosis (ALS) or related conditions.
✕Less likely to help
Patients with non-neurological conditions or those who do not have a diagnosis related to ALS may not benefit from this research.
What this research studies
This research investigates a novel method for tagging RNA and ribonucleoprotein complexes (RNPs) within cells to better understand their behavior and interactions. By using specially designed probes that target specific RNA structures, the study aims to track RNA movement and modifications in real-time. This approach could provide insights into RNA folding, trafficking, and the regulatory pathways involved in diseases like ALS. Patients may benefit from a deeper understanding of the molecular mechanisms underlying their conditions, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating ALS and other degenerative neurological disorders.
How similar studies have gone: While this approach is innovative, similar methodologies have shown promise in other areas of RNA research, suggesting potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bong, Dennis — Ohio State University
- Study coordinator: Bong, Dennis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.