Tracking rapid protein interactions that drive cancer
Mapping Dynamic Changes in Protein Interactome using Proximity Labeling with High Temporal Resolution
Builds faster lab tools to capture very short-lived protein connections in cancer cells so researchers can find better treatment targets.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11252879 on NIH RePORTER |
What this research studies
This project will develop lab methods that quickly tag proteins that are near each other inside living cancer cells, capturing interactions that happen in under a minute. The team will improve a biotin-based labeling approach so weak or transient protein partners can be detected with much better sensitivity. These tools are meant for use in cell and tissue samples to reveal how cancer signals are assembled and disassembled. Better maps of these interactions could point researchers to new targets for drug development.
Who could benefit from this research
Good fit: Patients would not be directly enrolled in this lab-focused project, but people with cancer who donate tumor or tissue samples to related research could contribute.
Not a fit: Patients seeking immediate changes in their own treatment are unlikely to see direct benefit from this early-stage laboratory methods work.
Why it matters
Potential benefit: If successful, the tools could speed discovery of important cancer targets and help guide the development of more precise therapies.
How similar studies have performed: Proximity labeling (e.g., BioID/TurboID) is an established technique for mapping protein partners, but achieving reliable labeling on minute-or-faster timescales is novel and less proven.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Karginov, Andrei V — University of Illinois at Chicago
- Study coordinator: Karginov, Andrei V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.