Tracking organ damage and immune exhaustion during sepsis using blood samples
Cell-free DNA epigenomics to track the dynamics of organ damage and immune exhaustion during sepsis
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-10869953
This study is looking at how sepsis impacts the body by checking blood samples from patients in intensive care, with the hope of finding better ways to monitor and treat those affected by this serious condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10869953 on ClinicalTrials.gov |
What this research studies
This research investigates how sepsis affects the body by analyzing cell-free DNA from daily blood samples of patients in intensive care. The goal is to understand the dynamics of organ damage and immune system exhaustion that contribute to severe outcomes in sepsis. By using advanced techniques like genome-wide methylation sequencing, researchers aim to identify which organs are being harmed and how T cells are becoming exhausted. This approach could lead to better monitoring and treatment strategies for patients suffering from sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients admitted to intensive care units with a diagnosis of sepsis.
Not a fit: Patients who are not diagnosed with sepsis or those who are not admitted to intensive care units may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for tracking and treating sepsis, potentially reducing mortality rates.
How similar studies have performed: Other research has shown promise in using cell-free DNA analysis for monitoring various conditions, suggesting that this approach could be effective for sepsis as well.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAUDHURI, AADEL — MAYO CLINIC ROCHESTER
- Study coordinator: CHAUDHURI, AADEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.