Tracking myelin loss and repair after ischemic stroke with MRI
Quantitative clinical imaging of demyelination and remyelination in ischemic stroke
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11252548
This project uses a new MRI technique to measure myelin loss and recovery in people who have had an ischemic stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11252548 on ClinicalTrials.gov |
What this research studies
If you have had an ischemic stroke, researchers will use a new type of MRI to directly measure myelin loss and later recovery in your brain. Patients will receive MRI scans soon after their stroke and at follow-up visits so doctors can track changes in myelin over time. The team will compare the MRI myelin measurements with clinical details and how well people recover function. This work builds on animal findings and aims to show the MRI approach can link brain repair to real recovery in people.
Who could benefit from this research
Good fit: Adults who recently experienced an ischemic (blockage) stroke and can safely undergo MRI scans are the ideal candidates.
Not a fit: People with hemorrhagic strokes, unstable medical problems, implanted MRI-incompatible devices, or those unable to travel to the study site are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could give doctors a clearer way to monitor brain repair after stroke and help predict or guide recovery.
How similar studies have performed: Animal studies have shown myelin damage and repair after stroke, but using this specific quantitative MRI to track remyelination in people is relatively new.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YARNYKH, VASILY L. — UNIVERSITY OF WASHINGTON
- Study coordinator: YARNYKH, VASILY L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.