Tracking multiple gene expressions in real-time using CRISPR technology
Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10918789
This study is exploring a new way to track how genes are working in your body using cutting-edge technology, which could help us better understand immune responses in conditions like cancer and improve treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10918789 on ClinicalTrials.gov |
What this research studies
This research aims to enhance our understanding of gene expression by using advanced CRISPR technology to monitor the activity of multiple cytokines simultaneously within tissues. By developing a system that can report on gene expression dynamically, the research seeks to overcome the limitations of traditional methods that only provide static snapshots of gene activity. Patients may benefit from this work as it could lead to improved insights into how immune responses function in various conditions, particularly in relation to cancer and immunotherapy. The approach involves optimizing detection capabilities and utilizing a novel encoding strategy to allow for multiplexed detection of gene expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing immunotherapy for cancer or those with conditions influenced by cytokine activity.
Not a fit: Patients with conditions unrelated to cytokine expression or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies by providing deeper insights into immune cell behavior and cytokine dynamics.
How similar studies have performed: Previous studies have shown promise in using CRISPR technology for gene expression monitoring, indicating a potential for success in this novel approach.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ISHIZUKA, JEFFREY J. — YALE UNIVERSITY
- Study coordinator: ISHIZUKA, JEFFREY J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.