Tracking multiple gene expressions in real-time using CRISPR technology
Official title: Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation
Funded at Yale University · NIH-10918789 · Data updated 2026-11-12
This study is exploring a new way to track how genes are working in your body using cutting-edge technology, which could help us better understand immune responses in conditions like cancer and improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $234,919 |
| NIH project number | 1R61CA291201-01 |
| Project ID | NIH-10918789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing immunotherapy for cancer or those with conditions influenced by cytokine activity.
✕Less likely to help
Patients with conditions unrelated to cytokine expression or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research aims to enhance our understanding of gene expression by using advanced CRISPR technology to monitor the activity of multiple cytokines simultaneously within tissues. By developing a system that can report on gene expression dynamically, the research seeks to overcome the limitations of traditional methods that only provide static snapshots of gene activity. Patients may benefit from this work as it could lead to improved insights into how immune responses function in various conditions, particularly in relation to cancer and immunotherapy. The approach involves optimizing detection capabilities and utilizing a novel encoding strategy to allow for multiplexed detection of gene expression.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies by providing deeper insights into immune cell behavior and cytokine dynamics.
How similar studies have gone: Previous studies have shown promise in using CRISPR technology for gene expression monitoring, indicating a potential for success in this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ishizuka, Jeffrey J. — Yale University
- Study coordinator: Ishizuka, Jeffrey J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.