Tracking kidney disease and heart health in adults
Official title: Prospective renal insufficiency cohort evaluation: PRICE
Funded at University of Pennsylvania · NIH-11131098 · Data updated 2026-11-12
This project follows adults with reduced kidney function to learn how kidney disease progresses and how it affects heart health and other health problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 28, 2001 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $280,261 |
| NIH project number | 5U01DK060984-25 |
| Project ID | NIH-11131098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (usually 21 years and older) with reduced kidney function or chronic kidney disease who can attend clinic visits at a participating center.
✕Less likely to help
People without reduced kidney function, or those already on dialysis or with a kidney transplant, may not be eligible or receive direct benefit from this cohort.
What this research studies
If you join, researchers will collect medical histories, blood and urine samples, heart tests, and questionnaires over many years to track health changes. The study follows a diverse group of adults with chronic kidney disease across multiple U.S. clinical centers, including the Penn site that enrolled over 700 people. Collected data include biological measurements, physiological tests, and social and patient-reported information to link kidney changes with cardiovascular outcomes. Long-term follow-up and stored samples help the team find markers that predict worsening kidney function and heart complications.
Why it matters
Potential benefit: Results could help identify markers and risk factors to slow kidney disease, prevent heart complications, and guide future treatments.
How similar studies have gone: Large cohorts like CRIC have already produced many important findings linking CKD progression to cardiovascular disease, so this continuation builds on proven success.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Cohen, Debbie L — University of Pennsylvania
- Study coordinator: Cohen, Debbie L
Related research
Other NIH-funded projects on the same topics.
-
Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
-
Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
-
Understanding Kidney Disease and Heart Health
This long-running project gathers information from people with reduced kidney function to better understand how kidney disease progresses and affects heart health.
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Johns Hopkins continuation of the Chronic Kidney Disease (CRIC) cohort
This project continues long-term follow-up of adults with chronic kidney disease to collect health information, tests, and samples that help understand kidney and heart complications.
-
Tulane Chronic Kidney Disease (CKD) Cohort
Following thousands of adults with reduced kidney function to learn what factors influence kidney decline and heart disease risk.
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Long-term chronic kidney disease follow-up at Case Western Reserve
Researchers will continue following adults with chronic kidney disease to track kidney health and heart problems over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.