Tracking how cells change during early embryonic development
Single Cell Tracking of 3D Epigenetic Landscape Evolution During Embryonic Development
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11045054
This study is looking at how cells change during the early stages of development, using special tools to see how genes are turned on and off, which could help us understand how cells decide what they will become.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11045054 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic changes in the epigenetic landscape of cells during the early stages of embryonic development. By using advanced techniques like fluorescence resonance energy transfer (FRET) biosensors, the study aims to monitor specific histone modifications at the single-cell level. This approach will help researchers understand how gene regulation occurs as cells begin to differentiate and make fate decisions. The findings could provide insights into the fundamental processes that guide cell development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of early development, particularly those with conditions related to developmental disorders.
Not a fit: Patients with fully developed conditions unrelated to embryonic development or genetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of embryonic development and potentially lead to advancements in regenerative medicine and developmental biology.
How similar studies have performed: Other research has shown success in using advanced imaging techniques to study cellular processes, indicating that this approach has the potential for significant findings.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YINGXIAO — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: WANG, YINGXIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.