Tracking how brain cells migrate to repair tissue damage
MR Imaging of Bioscaffold-Induced Neural Progenitor Migration
This study is looking at how special brain cells that help repair damage move to injured areas after a special gel is placed in the brain, and it aims to find ways to improve treatments for brain injuries that could help patients heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10875405 on NIH RePORTER |
What this research studies
This research investigates how neural progenitor cells, which are crucial for brain tissue regeneration, migrate to areas of damage in the brain after the implantation of a special hydrogel. Using advanced MR imaging techniques, the study aims to visualize and track these cells as they move from their origin in the subventricular zone to the site of the hydrogel implant. By understanding the timing and pathways of this migration, researchers hope to enhance strategies for brain repair and regeneration. Patients may benefit from insights gained about neurogenesis and potential new treatments for brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced brain injuries or strokes.
Not a fit: Patients with non-neurological conditions or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for brain tissue regeneration after injuries such as strokes.
How similar studies have performed: Previous research has shown promise in using similar imaging techniques to track cell migration, indicating potential for success in this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Modo, Michel M. — University of Pittsburgh at Pittsburgh
- Study coordinator: Modo, Michel M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.