Tracking gene-corrected stem cells in ALS patients
Non-Invasive Tracking of Genome-Corrected iPS cells in ALS
This study is looking at how gene-edited stem cells can help treat ALS by using special imaging techniques to see how well these cells work in your body, which could lead to more personalized treatments just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10472760 on NIH RePORTER |
What this research studies
This research investigates the use of gene-edited stem cells, specifically patient-derived induced pluripotent stem cells (iPSCs), for treating amyotrophic lateral sclerosis (ALS). The study aims to develop non-invasive imaging techniques to monitor the distribution and survival of these transplanted cells in real-time. By employing advanced imaging modalities, including magnetic particle imaging (MPI), PSMA-targeted PET, and MRI, researchers hope to gain insights into the effectiveness and safety of cell replacement therapies. This approach could lead to personalized treatment strategies for ALS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with familial or sporadic ALS, particularly those with known genetic mutations.
Not a fit: Patients with non-genetic forms of ALS or those who are not candidates for stem cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic avenue for ALS patients by enabling effective monitoring of gene-corrected stem cell therapies.
How similar studies have performed: Previous research has shown promise in using similar imaging techniques for tracking stem cells, indicating potential success for this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bulte, Jeff W. — Johns Hopkins University
- Study coordinator: Bulte, Jeff W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.