Tracking frontotemporal lobar degeneration and its inherited forms
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)
This project follows people with frontotemporal lobar degeneration (FTLD), including those with known genetic mutations, over time to improve diagnosis and find biological markers that could guide future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11398814 on NIH RePORTER |
What this research studies
If you join, the team will collect clinical visits, cognitive testing, brain scans, genetic tests, and biological samples over months and years to watch how FTLD changes. The project enrolls both people with sporadic FTLD and those from families with MAPT, GRN, or C9orf72 mutations. Data and samples are shared across a network of clinics to speed discovery of disease-specific biomarkers and patterns. The long-term goal is to match future therapies to the right patients and to measure whether those therapies work.
Who could benefit from this research
Good fit: Adults with clinical signs of FTLD or people from families with known FTLD-related gene mutations (MAPT, GRN, C9orf72) are the most likely candidates.
Not a fit: People without FTLD symptoms, without relevant genetic risk, or those seeking an immediate treatment are unlikely to receive direct clinical benefit from participation.
Why it matters
Potential benefit: This work could lead to earlier and more accurate diagnosis, better ways to track disease progression, and identification of targets for therapies.
How similar studies have performed: Previous ARTFL/LEFFTDS efforts have built large patient cohorts and biomarker datasets, improving research infrastructure though effective disease‑modifying treatments are not yet available.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Boeve, Bradley F — Mayo Clinic Rochester
- Study coordinator: Boeve, Bradley F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.