Tracking drug-resistant gonorrhea using advanced genetic testing.
Official title: Whole Genome Sequencing of N. gonorrhoeae from Non-Culture Based Clinical Specimens to Surveil for Emerging Resistance
Funded at Rush University Medical Center · NIH-10951805 · Data updated 2026-11-12
This study is looking at how drug-resistant gonorrhea spreads, especially in communities like men who have sex with men, to help improve health responses and understand the effects of COVID-19 on gonorrhea rates.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $243,361 |
| NIH project number | 1R21AI185529-01 |
| Project ID | NIH-10951805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with gonorrhea, particularly those from communities with high rates of drug resistance.
✕Less likely to help
Patients who do not have gonorrhea or are not part of high-risk communities may not benefit from this research.
What this research studies
This research focuses on understanding the spread of drug-resistant Neisseria gonorrhoeae, a significant public health threat. By utilizing whole genome sequencing on clinical specimens that are not typically cultured, the study aims to identify emerging strains of gonorrhea and their resistance patterns. This approach will enhance surveillance efforts, particularly in communities heavily affected by the disease, such as men who have sex with men. The research also addresses the impact of the COVID-19 pandemic on gonorrhea rates and aims to improve public health responses.
Why it matters
Potential benefit: If successful, this research could lead to better detection and management of drug-resistant gonorrhea, ultimately improving patient outcomes.
How similar studies have gone: Previous research has successfully utilized whole genome sequencing for other bacterial infections, indicating potential for success in this novel application.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Popovich, Kyle Jeanne — Rush University Medical Center
- Study coordinator: Popovich, Kyle Jeanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.