Tracking changes in childhood leukemia that resist treatment
Tracking Therapy-Resistant Alterations in Childhood Acute Lymphoblastic Leukemia
This study is looking at why some kids with acute lymphoblastic leukemia (ALL) don’t respond to treatment and aims to find ways to better predict which patients might have a relapse, so doctors can tailor their care and improve outcomes for young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10911272 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain childhood acute lymphoblastic leukemia (ALL) cells become resistant to treatment. By analyzing genetic changes in these cells at the time of diagnosis, the researchers aim to develop better risk models that can predict which patients are more likely to relapse after initial therapy. The study will utilize advanced genomic techniques to identify resistance drivers and improve treatment strategies, ultimately aiming to reduce the incidence of relapse and associated late effects. This approach seeks to personalize therapy for young patients based on their unique cancer profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with acute lymphoblastic leukemia.
Not a fit: Patients with leukemia types other than acute lymphoblastic leukemia or those outside the age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment plans for children with leukemia, reducing the risk of relapse and long-term health complications.
How similar studies have performed: Previous research has shown promise in using genomic approaches to understand cancer resistance, indicating that this methodology could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Ma, Xiaotu — St. Jude Children's Research Hospital
- Study coordinator: Ma, Xiaotu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.