Tracking brain inflammation in different types of Alzheimer's disease
Longitudinal imaging of microglial activation in different clinical variants of Alzheimer's disease
This study is looking at how brain inflammation affects the progression of Alzheimer's disease, and it's for people with specific types of Alzheimer's to help find the best times for possible treatments that could slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893953 on NIH RePORTER |
What this research studies
This research investigates how inflammation in the brain, specifically through the activation of microglia, relates to the progression of Alzheimer's disease (AD). Using advanced PET imaging techniques, the study aims to understand the timing and location of microglial activation in relation to tau pathology and neurodegeneration. By enrolling patients with specific clinical variants of AD, the research seeks to identify critical time points for potential therapeutic interventions that could modify the disease's course. The findings may help in developing targeted treatments based on individual patient profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with specific clinical variants of Alzheimer's disease, such as amnestic AD, posterior cortical atrophy, or logopenic variant.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without a confirmed diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglial activation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Small, Scott a — Columbia University Health Sciences
- Study coordinator: Small, Scott a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.