Tracking blood stem cells in living mice
Official title: Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo
Funded at University of Wisconsin-Madison · NIH-11036635 · Data updated 2026-11-12
This study is looking at how blood-forming stem cells work in living mice to learn more about how they change and react to things like aging and stress, which could help us understand blood diseases and cancers better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $217,533 |
| NIH project number | 1R21OD037861-01 |
| Project ID | NIH-11036635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those at risk for blood cancers, particularly as they age.
✕Less likely to help
Patients with non-hematological conditions or those who are not affected by blood diseases may not benefit from this research.
What this research studies
This research focuses on understanding how hematopoietic stem cells (HSCs) and their progenitors behave in their natural environment within living mice. By using advanced techniques to label and track these cells, the researchers aim to uncover how HSCs differentiate and respond to various conditions, such as aging and stress. This could lead to better insights into blood diseases and cancers that arise from improper cell differentiation. The study utilizes innovative multicolor mouse models to visualize these processes in real-time.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood cancers and other blood-related diseases by enhancing our understanding of stem cell behavior.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study stem cells, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Tamplin, Owen James — University of Wisconsin-Madison
- Study coordinator: Tamplin, Owen James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.