Tracking blood stem cells in living mice
Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo
This study is looking at how blood-forming stem cells work in living mice to learn more about how they change and react to things like aging and stress, which could help us understand blood diseases and cancers better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11036635 on NIH RePORTER |
What this research studies
This research focuses on understanding how hematopoietic stem cells (HSCs) and their progenitors behave in their natural environment within living mice. By using advanced techniques to label and track these cells, the researchers aim to uncover how HSCs differentiate and respond to various conditions, such as aging and stress. This could lead to better insights into blood diseases and cancers that arise from improper cell differentiation. The study utilizes innovative multicolor mouse models to visualize these processes in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or those at risk for blood cancers, particularly as they age.
Not a fit: Patients with non-hematological conditions or those who are not affected by blood diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood cancers and other blood-related diseases by enhancing our understanding of stem cell behavior.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to study stem cells, indicating that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Tamplin, Owen James — University of Wisconsin-Madison
- Study coordinator: Tamplin, Owen James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.