Tracking biomarkers to delay the onset of dementia in at-risk individuals
Official title: Biomarkers to Track Effective Interventions that Delay Dementia Onset in Participants of the "Risk Reduction for Alzheimer's Disease (rrAD)" Trial
Funded at University of Kentucky · NIH-10746197 · Data updated 2026-11-12
This study is looking at how certain blood markers can help us understand if different treatments, like exercise and medications, are working to delay dementia in people at risk for Alzheimer's disease, so we can learn how lifestyle changes might improve brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,297,829 |
| NIH project number | 1RF1AG084134-01 |
| Project ID | NIH-10746197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are at risk for Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not at risk for Alzheimer's disease or related dementias may not receive any benefit from this research.
What this research studies
This research investigates how certain biomarkers can help track the effectiveness of interventions aimed at delaying the onset of dementia, particularly in individuals at risk for Alzheimer's disease. The study involves participants from the 'Risk Reduction for Alzheimer's Disease' trial, who are undergoing various interventions, including pharmacological treatments and aerobic exercise. By analyzing plasma-based biomarkers and neuroimaging data collected over two years, the research aims to clarify the relationship between cardiovascular risk factors, physical activity, and cognitive decline. This could provide valuable insights into how lifestyle changes can impact brain health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for delaying the onset of dementia, enhancing the quality of life for at-risk individuals.
How similar studies have gone: Previous research has shown promise in using lifestyle interventions to impact cognitive health, but this specific approach utilizing biomarkers is relatively novel.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Stowe, Ann Marie — University of Kentucky
- Study coordinator: Stowe, Ann Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.