Tracking antibiotic resistance in patients after stem cell transplants
Official title: Precision characterization of antimicrobial resistance gene dynamics in bloodstream infection risk after hematopoietic stem cell transplantation
Funded at Univ of North Carolina Chapel Hill · NIH-10898755 · Data updated 2026-11-12
This study is looking at how antibiotic-resistant bacteria grow and spread in patients who have had stem cell transplants, with the hope of finding ways to prevent infections and keep you healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $202,619 |
| NIH project number | 5K23AI163365-04 |
| Project ID | NIH-10898755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are undergoing hematopoietic stem cell transplantation and are at risk for infections.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those with no history of antibiotic use may not benefit from this research.
What this research studies
This research focuses on understanding how antibiotic-resistant bacteria develop and spread in patients who have undergone hematopoietic stem cell transplantation. By utilizing advanced sequencing technologies, the study aims to identify specific resistance genes present in the gut flora of these immunocompromised individuals. The goal is to design effective clinical strategies to prevent serious infections caused by multidrug-resistant organisms, ultimately improving patient outcomes. Patients will be monitored to assess the dynamics of these resistant bacteria and their impact on infection risk.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for infections in patients undergoing stem cell transplants, reducing the risk of untreatable infections.
How similar studies have gone: Previous research has shown promising results in tracking antibiotic resistance in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Andermann, Tessa — Univ of North Carolina Chapel Hill
- Study coordinator: Andermann, Tessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.