Tracking antibiotic resistance in patients after stem cell transplants
Precision characterization of antimicrobial resistance gene dynamics in bloodstream infection risk after hematopoietic stem cell transplantation
This study is looking at how antibiotic-resistant bacteria grow and spread in patients who have had stem cell transplants, with the hope of finding ways to prevent infections and keep you healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10898755 on NIH RePORTER |
What this research studies
This research focuses on understanding how antibiotic-resistant bacteria develop and spread in patients who have undergone hematopoietic stem cell transplantation. By utilizing advanced sequencing technologies, the study aims to identify specific resistance genes present in the gut flora of these immunocompromised individuals. The goal is to design effective clinical strategies to prevent serious infections caused by multidrug-resistant organisms, ultimately improving patient outcomes. Patients will be monitored to assess the dynamics of these resistant bacteria and their impact on infection risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are undergoing hematopoietic stem cell transplantation and are at risk for infections.
Not a fit: Patients who are not undergoing stem cell transplantation or those with no history of antibiotic use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for infections in patients undergoing stem cell transplants, reducing the risk of untreatable infections.
How similar studies have performed: Previous research has shown promising results in tracking antibiotic resistance in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Andermann, Tessa — Univ of North Carolina Chapel Hill
- Study coordinator: Andermann, Tessa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.