Tracing and modifying brain connections in zebrafish
Development and Validation of a Genetically Encoded Method to Trace and Manipulate Neuronal Circuits in Zebrafish
This study is exploring a new way to see and change how brain cells connect in zebrafish, which could help us understand how the brain works and how diseases like Alzheimer's affect it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10505822 on NIH RePORTER |
What this research studies
This research focuses on developing a new genetic method to visualize and manipulate the connections between neurons in the brains of zebrafish. By using this innovative approach, researchers aim to better understand how brain circuits function and how they may be affected by diseases like Alzheimer's. The zebrafish model is particularly advantageous due to its transparent embryos and the ability to observe complex behaviors early in development. This study will utilize advanced genetic tools to identify and modify specific neuronal circuits, providing insights into brain function and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients with neurological conditions other than Alzheimer's or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating neurodegenerative diseases such as Alzheimer's.
How similar studies have performed: Previous research using similar genetic manipulation techniques in model organisms has shown promising results, indicating potential for success in this novel approach.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Prober, David Aaron — California Institute of Technology
- Study coordinator: Prober, David Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.